Products     Intellec - Mode of Action Bacopa monnieri (Brahmi) – Improves cognitive function Controlling for baseline cognitive deficit using the Blessed Orientation-Memory-Concentration test, Bacopa participants had enhanced AVLT (Auditory Verbal Learning Test) delayed word recall memory scores relative to placebo. Stroop results were similarly significant, with the Bacopa group improving and the placebo group unchanged. CESD-10 (Center for Epidemiologic Studies Short Depression ) depression scores, combined state plus trait anxiety scores, and heart rate decreased over time for the Bacopa group but increased for the placebo group. No effects were found on the DAT( Divided attention task), WAIS (Wechsler Adult Intelligence Scale) digit task, mood, or blood pressure. The dose was well tolerated with few adverse events (Bacopa n = 9, placebo n = 10), primarily stomach upset. (J Altern Complement Med.2008 Jul;14(6):707-13)   Centella asiatica (Mandukparni) – Anti oxidant and neuro regenerative CA protected MSG( Monosodium glutamate) induced neurodegeneration attributed to its antioxidant and behavioural properties. This activity of CA can be explored in epilepsy, stroke and other degenerative conditions in which the role of glutamate is known to play vital role in the pathogenesis. (Indian J Exp Biol.2007 May;45(5):425-31)   Nardostachys jatamansi (Jatamansi) – Anxiolytic and Anti depressant There was a significant increase in despair behaviour and anxiety in stressed control animals on successive days of CFS (Chronic fatigue syndrome). Locomotor activity gradually decreased in stressed control group. Treatment with NJE (200 and 500 mg/kg) significantly reversed both paradigms. Biochemical analysis showed that CFS significantly increased lipid peroxidation, nitrite and superoxide dismutase levels and decreased catalase level in rat brain. Administration of NJE (200 and 500 mg/kg) tended to normalize both augmented lipid peroxidation, nitrite, superoxide dismutase activities and catalase level significantly showing anti oxidant action. (Behav Brain Res 2009 Sep 14; 202(2):285-90)   Acorus calamus (Vacha) – Anti oxidant and Anti stress The results indicated that during exposure of noisy environment ROS generation led to increase in corticosterone, LPO( lipid peroxidation) and SOD (superoxide dismutase), but decrease in CAT(catalase), GPx (glutathione peroxidase), GSH (glutathione), protein thiols, vitamins C and E levels. Both the ethyl acetate and methanolic extract of Acorus calamus protected most of the changes in the rat brain induced by noise-stress. (Biol Pharm Bull.2005 Dec; 28(12):2327-30)   Withania somnifera (Ashwagandha) – Anti stress and Adaptogenic The results indicate that WS (Withania somnifera), has significant antistress adaptogenic activity, confirming the clinical use of the plant in Ayurveda. (Pharmacol Biochem Behav. 2003 Jun;75(3):547-55)